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KMID : 1200820110110040293
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 4 p.293 ~ p.298
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Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion
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Mandade Rajesh
Sreenivas S. A.
Sakarkar D. M.
Wanare Ravi
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Abstract
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Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of Carthamus tinctorius L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of Carbachol induced gastric secretion and to compare the results with that of Cimetidine and Verapamil on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, Cimetidine 2.5 mg/kg and Carbachol 600 μg/kg and Verapamil 10 mg/kg body weight, intraperitoneally, in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P?
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KEYWORD
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Antiulcer, Verapamil, Cimetidine, Carbachol, Carthamus tinctorius
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