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KMID : 1200820120120010041
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Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 1 p.41 ~ p.50
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Comparative antihyperglycaemic and antihyperlipidemic effect of Origanum majorana extracts in NIDDM rats
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Pimple B. P.
Kadam P. V.
Patil M. J.
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Abstract
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Diabetes mellitus is a metabolic disorder prevailing throughout the world irrespective of age, sex and race. The present study deals with phytochemical, antioxidant, antihyperglycaemic and antihyperlipidemic potential of Origanum majorana (OM) leaves. Various extracts of OM were used for the study such as, hydrodistilled volatile oil (OMO), petroleum ether extract (OMPE), methanolic extract (OMM) and aqueous extract (OMW). Three doses of each extract viz. 100, 200 and 400 mg/kg p.o. were used for the study. Streptozotocin, STZ (65 mg/Kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non insulin dependent diabetes mellitus (NIDDM) in rats. Various biochemical markers of blood and tissue origin were estimated. The results were statistically analyzed by ANOVA followed by Dunnett’s test. Glibenclamide, a well known antidiabetic drug, was used as a standard. Volatile oil (OMO, 200 and 400 mg/kg p.o.) and methanolic extract (OMM, 200 and 400 mg/kg p.o.) exhibited dose dependent significant (p?
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KEYWORD
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Antioxidant, Antihyperglycaemic, Glibenclamide, Origanum majorana, Streptozotocin
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