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KMID : 1200820120120010051
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Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 1 p.51 ~ p.58
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Formulation, standardization and pharmacological evaluation of a poly herbal traditional remedy -Ashwagandharishtam
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Rasheed Arun
Roja C.
Reddy G. Avinash Kumar
Reddy B. Sravya
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Abstract
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Ayurvedic formulations were considered the best and safer alternatives for synthetic drugs. But the demand to such products is diminishing due to lack of standardization. Ashwagandharishtam, a fermented kind of ayurvedic formulation, is used to treat epilepsy, nervous disorders, skin diseases, immune disorders and rheumatism. In the present study, the standardization of Ashwagandharishtam using sophisticated techniques were attempted for assessing the quality and safety of herbal products involved in it. It was formulated according to a working formula and its physico-chemical, pharmacological and biological parameters were determined. The results of physicochemical studies showed that the values were under acceptable limits as per the Ayurvedic Pharmacopoeial specifications. FTIR studies of formulation revealed the presence of functional groups similar to Ashwagandha powder. The heavy metal content in the formulation is determined using Atomic Absorption Spectroscopy. HPTLC reports proved the presence of biomarker, withanolide-A in ashwagandharishtam which helped in its chemical standardization. The anti-epileptic activity of ashwagandharishtam was evaluated by Maximal electro shock (MES) method in rats. It exhibited a dose dependent significant (P?
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KEYWORD
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Standardization, Ashwagandharishtam, Withanolides, Antiepileptic activity, Anti-inflammatory activity
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