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KMID : 1200820120120020107
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Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 2 p.107 ~ p.111
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Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells
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Choi In-Young
Kim You-Jeong
Kee Ji-Ye
Kim Min-Chol
Lee Dong-Jin
Cho Sung-One
Ko Jang-Ho
Kim Dae-Seung
Jeon Yong-Deok
Yoon Cheol-Hee
Park Yun-Jum
Um Jae-Young
Hong Seung-Heon
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Abstract
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Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.
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KEYWORD
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Mulberry leaf, Ulcerative colitis, DSS, Nitrite oxide, Anti-inflammation
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