|
KMID : 1200820120120030167
|
|
Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 3 p.167 ~ p.175
|
|
|
Effect of Cynodon dactylon on rotenone induced Parkinson’s disease
|
|
Sharma Neha
Bafna Pallavi
|
|
|
Abstract
|
|
|
|
In the present study, the aqueous extract of Cynodon dactylon (AECD) Pers. (Graminae) was evaluated for anti-parkinson’s activity in rats. The anti-parkinson’s effect of AECD was studied against rotenone (2 mg/kg, s.c.) - induced parkinsons in rats. In this study, chronic administration of rotenone in rats (28 days) produced motor dysfunctions like catalepsy and muscle rigidity along with a reduction in locomotor activity. Rotenone administration was also found to generate oxidative stress in the brain as evident from an increase in the level of TBARS and decrease in the levels of SOD and GSH. Pretreatment with AECD resulted in a significant (p?
|
|
|
KEYWORD
|
|
|
Cynodon dactylon, Rotenone, Parkinsons, Catalepsy, Oxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|