KMID : 1200820120120030181
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Oriental Pharmacy and Experimental Medicine 2012 Volume.12 No. 3 p.181 ~ p.188
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Evaluation of anti-inflammatory and antioxidant potential of the kernel root of Xylocarpus mekongensis (Lamk.) M. Roem
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Jahan Ismet Ara
Hossain Hemayet Nimmi Ishrat Islam Siblara Kawsar Hassan Islam Amirul
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Abstract
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Anti-inflammatory and antioxidant activities of the crude ethanolic extract of the kernel root of Xylocarpus mekongenesis (Lamk.) M. Roem. (Meliaceae) was evaluated in different methods. The extract showed significant anti-inflammatory activity in carrageenan-induced oedema test in rats showing 69.42 % reduction in the paw volume (P?0.01) comparable to that produced by the standard drug indomethacin (70.25 %) at 24 h when the extract was fed at the dose of 400 mg/kg body weight. The percentage inhibition of the oedema paw volume was statistically significant (p?0.05) when compared with the indomethacin treated animals at 0.5, 1, 2, 4 and 6 h. The extract exhibited IC50 value 4.78 ¥ìg/ml in DPPH free radical scavenging activity test that was found to be very significant and comparable to that of the standard antioxidants ascorbic acid and BHA (1.9372 and 4.81 ¥ìg/ml) respectively. In nitric oxide radical scavenging test, the IC50 value was also found fairly significant 57.37 ¥ìg/ml when compared to standard ascorbic acid (36.81 ¥ìg/ml). In reducing power test, the maximum absorbance of the same extract was observed as 1.923 at 100 ¥ìg/ml and that of ascorbic acid and BHA were 2.8111 and 1.0314 respectively. The extract showed highest antioxidant capacity at 100 ¥ìg/ml concentration expressed as equivalents of ascorbic acid (1.44). The total phenolic content of the extract was also found quite high (342.15?¡¾?0.92 mg/g of gallic acid equivalent). Therefore, the results of this study suggest the probable anti-inflammatory and antioxidant activities of the ethanolic extract of X. mekongenesis kernel root and justify its use in traditional medicines.
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KEYWORD
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Xylocarpus mekongensis, Anti-inflammatory, DPPH free-radical scavenging, Nitric oxide scavenging, Reducing power, Total antioxidant capacity, Total phenolic
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