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KMID : 1200820120120040255
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Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 4 p.255 ~ p.264
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Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals
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Patil Mithun Vishwanath K.
Kandhare Amit D.
Ghosh Pinaki
Bhise Sucheta D.
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Abstract
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The aim of the present study was to investigate anticonvulsant effect of Fragaria vesca L. ethanolic etract in chemically induced epilepsy.Fragaria vesca L. ethanolic extract (FVEE) was prepared by extracting the fruit with 95 % ethanol. Seizures were induced by intraperitoneal injection of pentylenetetrazole, strychnine, isoniazid and subcutaneous injection of picrotoxin in male swiss albino mice. The in-vitro parameters were also determined including brain gamma amino butyric acid, nitric oxide.Single dose of PTZ, PTX, STR and INH resulted in resulted in hind-limb, tonic-clonic convulsion along with mortality in mice. Treatment with FVEE (250 and 500 mg/kg, p.o.) significantly and dose dependently (P?
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KEYWORD
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Brain GABA, Epilepsy, Fragaria vesca L., Isoniazid, Nitric oxide, Pentylenetetrazole, Picrotoxin
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