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KMID : 1200820120120040287
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Oriental Pharmacy and Experimental Medicine
2012 Volume.12 No. 4 p.287 ~ p.299
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Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker
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Kandhare Amit D.
Kumar V. Shiva
Adil Mohammad
Rajmane Anuchandra R.
Ghosh Pinaki
Bodhankar Subhash L.
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Abstract
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Peptic ulcer owes its pathological features to disregulated oxido-nitrosative and necrotic changes in gastrointestinal mucosa. Xanthium strumarium L. is a ubiquitous, abundant herb possessing an array of pharmacological properties. In view of anti-inflammatory and antioxidant activity of Xanthium strumarium L., the present investigation was designed to unravel its antiulcer potential in pylorus ligation induced gastric ulcer in laboratory animals. X. srtumarium L. leaves were extracted by refluxing with 95 % ethanol to obtained X. srtumarium L. ethanolic extract (XSEE). After 1 h pretreatment period of XSEE (100, 200 and 400 mg/kg) gastric ulcer was induced by ligation of pylorus portion of stomach. Various parameters including volume of gastric fluid, pH of gastric fluid, free as well as total acidity were measured in the gastric fluid whereas ulcer area, ulcer index, mucin content, superoxide dismutase, myeloperoxidase, nitric oxide, total calcium, histamine level, membrane bound inorganic phosphate (Na-K-ATPase), TNF-α level, DNA fragmentation were determined in the gastric tissue. Pretreatment with XSEE (200 and 400 mg/kg) significantly and dose dependently (P?
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KEYWORD
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Antiulcer, Calcium, DNA fragmentation, Histmaine, Na+K+ATPase, Nitric oxide, Oxidative stress, Tumor necrosis factor-α, Xanthium srtumarium L.
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