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KMID : 1200820130130010011
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 1 p.11 ~ p.20
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Hypolipidemic and antioxidant activity of grape skin extract and resveratrol on rats fed with high-fat diet
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Rajesh Venugopalan
Perumal Perumal
Aruna Ponnala
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Abstract
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Purple grapes are believed to be beneficial to human health. Many of the health benefits attributed to purple grapes are due to phytoconstituents that are concentrated largely in grape skin. Resveratrol, a polyphenol isolated from seeds and skin of grapes has shown a wide range of pharmacological activities including prevention of cancer and cardiovascular diseases. The present study was to evaluate the hypolipidemic and antioxidant activity of grape skin extract and resveratrol on rats fed with high-fat diet. The results showed that oral administration of grape skin extract 500 mg/kg body weight and resveratrol 20 mg/kg body weight showed a significant improvement in lipid profile. A significant reduction of atherogenic index was observed with grape skin extract 500 mg/kg body weight. In addition, high-fat diet induced changes in levels of hepatic tissue lipid peroxidation, superoxide dismutase, catalase and glutathione peroxidase were reverted back to normal levels by grape skin extract 500 mg/kg body weight. The histopathological investigation of liver showed normalization with grape skin extract 500 mg/kg body weight. These findings suggest that purple grape fruit, containing plenty of phytoconstituents has a great potential as a natural source beneficial for patients suffering from hypercholesterolemia and preventing or be helpful in reducing complications of dyslipidemia associated disorders.
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KEYWORD
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Grape skin, Resveratrol, High fat diet, Hypolipidemic, Invivo antioxidant
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