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KMID : 1200820130130010077
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 1 p.77 ~ p.84
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Reversal of perfluorooctanesulfonate-induced immunotoxicity by a glucan-resveratrol-vitamin C combination
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Vetvicka V.
Vetvickova J.
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Abstract
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Perfluorinated compounds (PFCs) perfluoroctanic acid (PFOA) and perfluooctane sulphonic acid (PFOS) are environmentally widespread bioaccumulative chemicals known to induce profound effects on the immune system. In this study, two types of PFC, i.e., PFOS and PFOA, were administered orally (daily) a dose of 20 mg/kg/d. After exposure, all mice exhibited significant immunosuppressive effects upon both cellular (phagocytosis and NK cell activity) and humoral (antibody response) branches of their immune responses. The mice were then fed with a 4 mg/kg/d dose of a combination of resveratrol-glucan-vitamin C (RVB 300). The results showed that treatment with PFCs and RVB 300 resulted in significantly lower level of immunotoxic effects from PFCs. These outcomes suggest to us that RVB 300 can potentially be successfully used as a natural remedy against immunotoxicities induced by low-level exposure(s) to perfluorinated compounds.
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KEYWORD
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Glucan, Immunotoxicity, Phagocytosis, Antibodies, PFOS, PFOA
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