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KMID : 1200820130130020113
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 2 p.113 ~ p.120
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In vitro xanthine oxidase inhibitory and antioxidant activities of aerial parts of Flacourtia sepiaria Roxb
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Sreejith M.
Kannappan N.
Santhiagu A.
Marathakam Akash
Ajith P. M.
Jasemine S
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Abstract
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The present study was carried out to investigate the in vitro xanthine oxidase inhibitory (XOI) and antioxidant activities of various extracts of the aerial parts of Flacourtia sepiaria Roxb which belongs to the family of Flacourtiaceae. Flacourtia sepiaria is traditionally used as an antidote for snake poisoning, rheumatoid arthritis, gout and kidney diseases. The XOI activity was evaluated by quantifying the decrease in absorbance of xanthine using U-V spectrophotometer. The antioxidant activities of the extract were determined by evaluating its DPPH, superoxide, hydroxyl, nitric oxide radical scavenging abilities, ferrous chelating ability, total phenolic content and flavonoid content. The XOI activity of the methanol extract (IC50?=?8.37?±?0.21) was found to be significant (P?
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KEYWORD
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Xanthine oxidase, Allopurinol, Flacourtia sepiaria, Antioxidant activity
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