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KMID : 1200820130130020133
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 2 p.133 ~ p.142
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Anticancer activity and chromatography characterization of methanol extract of Heritiera fomes Buch. Ham., a mangrove plant from Bhitarkanika, India
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Patra Jayanta Kumar
Thatoi Hrudayanath
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Abstract
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Heritiera fomes Buch. Ham., a dominant mangrove tree species occurring in Bhitarkanika mangrove forest, Odisha, India has been known for its ethnomedicinal uses for the treatment of gastrointestinal disorders, hepatic disorders, skin diseases, diabetes and goiter. Scientific evidence in support ethnomedicinal uses of this plant is lacking. Hence the study is aimed to determine the anticancer activity along with the partial characterization of methanol extract of H. fomes in both in vitro and in vivo by using animal model. The methanol extract of both leaf and stem powder showed anticancer properties with 40 % inhibition against B16 mouse melanoma (in vitro system) and Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice (in vivo system). The partial characterizations of the methanol extract by TLC, HPLC, 1H NMR and FTIR spectral analysis revealed phenolic as the lead compounds. Overall results showed that both the leaf and stem extracts of H. fomes possess strong anticancer properties along with the presence of most of the phytochemicals which supports previous claims of the traditional use for various diseases.
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KEYWORD
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Anticancer, Chromatography, HPLC, NMR, FTIR, Heritiera fomes, Bhitarkanika
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