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KMID : 1200820130130020149
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 2 p.149 ~ p.157
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Anti-nociceptive, CNS, antibacterial and antifungal activities of methanol seed extracts of Nephelium lappaceum L
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Rajasekaran Aiyalu
Ganesan Shunmugam
Kamini Nadarajah
Lavanya Chandramohan
Yoon Liew-Lee
Oh Hui Shian
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Abstract
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Methanol seed (raw, boiled and roasted) extracts of Nephelium lappaceum L (N. lappaceum) were investigated for anti-nociceptive, CNS, antibacterial and antifungal activities. Antinociceptive activity was evaluated by Eddy’s hot plate method. CNS activity was evaluated by rota rod and actophotometer. The antibacterial and antifungal activity was evaluated by cup plate method and by minimum inhibitory concentration (MIC) method. In acute toxicity, all three extracts was found to be safe up to 2,500 mg/kg dose. The anti-nociceptive activity exhibited by raw methanol seed extract was found to be superior than boiled methanol seed extracts. Roasted methanol seed extracts did not show any activity. In rota rod test, methanol extract of raw and boiled seed extracts were significantly (P?
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KEYWORD
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Nephelium lappaceum, Anti-nociceptive, Locomotor, Antibacterial and Antifungal activity
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