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KMID : 1200820130130030199
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 3 p.199 ~ p.204
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Anti-nociceptive activity of Mikania scandens flower in albino mice: involvement of CNS depressant role
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Bhattacharya Sanjib
Chandra Sangita
Dey Protapaditya
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Abstract
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Mikania scandens (L.) Willd. (Asteraceae), known as climbing hemp weed in English is a herbaceous climbing vine grown as a weed throughout the plains of the Indian subcontinent. The present study evaluated anti-nociceptive as well as central nervous system (CNS) activities of hydroalcoholic extract of flower from M. scandens (FMS) in Swiss albino mice. FMS (at 250 and 500 mg/kg body weight, i.p.) was evaluated for anti-nociceptive activity by acetic acid induced writhing and tail flick methods. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effect was evaluated by using rota-rod apparatus and sedative potentiating property by phenobarbitone-induced sleep potentiation study. The results of the present study revealed significant (p?
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KEYWORD
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Mikania scandens, CNS depressant, Muscle relaxant, Anti-nociceptive
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