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KMID : 1200820130130040247
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 4 p.247 ~ p.252
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Aqueous extract of purple Bordeaux radish, Raphanus sativus L. ameliorates ethanol-induced gastric injury in rats
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Ahn Mee-Jung
Koh Ryeo-Kyeong
Kim Gi-Ok
Shin Tae-Kyun
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Abstract
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The aim of this study was to evaluate whether the crude aqueous extract of purple Bordeaux radish (Raphanus sativus L.) (PBR) ameliorates ethanol-induced gastric injury in rats. Animals were divided into the following nine groups: normal, distilled water-treated vehicle control, groups orally administered PBR extract (250, 500 and 1,000 mg/kg, daily for 2 weeks), with or without ethanol treatment (5 ml/kg) 24 h after final administration of PBR extract, and a group treated with ethanol alone. Rats treated with PBR extract (250?1,000 mg/kg) for 2 weeks showed no significant effects on body weight and gastric mucosa. Pretreatment with PBR extract at doses of 500 and 1,000 mg/kg, but not 250 mg/kg, significantly ameliorated ethanol-induced gastric hemorrhages in rats (p?
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KEYWORD
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Anti-oxidation, Ethanol induced gastric injury, Gastroprotection, Radish
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