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KMID : 1200820130130040301
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 4 p.301 ~ p.306
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Neuroprotective effect of petroleum ether, methanolic and aqueous extracts of flower heads of Sphaeranthus indicus on lipofuscinogenesis and fluorescence product in brain of D-galactose induced aging accelerated mice
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Ambikar D. B.
Mohanta Guru Prasad
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Abstract
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Neuroprotective effect of petroleum ether (SIP), methanolic (SIM) and aqueous extract (SIA) obtained from Sphaeranthus indicus Linn was studied by the measurement of fluorescence product and biochemical parameter like lipid peroxidation, catalase activity and glutathione peroxides activity in the brains of D-galactose induced aging accelerated female albino mice. D-galactose administration is a well known model to accelerate normal aging. The 0.5 ml of 5 % D-galactose solution (sc) was administered to each mice for 15 days, which resulted in significant increase of fluorescence product and lipofuscin granule accumulation in cerebral cortex. Moreover lipid peroxidation increased and antioxidant enzymes like glutathione peroxides and catalase activity were decreased in cerebral cortex. Co-treatment of D-galactose with SIM or SIA (100 mg/kg, po) reduced the fluorescence product accumulated in the cerebral cortex. SIM was also protective against D-galatose-induced accelerated aging by reducing lipid peroxidation and restoring the enzymatic activity of glutathione peroxidase and catalase. In conclusion, SIM and SIA were found to be an effective neuroprotective agent which could reverse D-galactose-induced oxidative damage and acceleration of aging.
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KEYWORD
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Fluorescence product, Lipid peroxidation, Lipofuscin granules, Sphaeranthus indicus
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