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KMID : 1200820130130040327
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Oriental Pharmacy and Experimental Medicine
2013 Volume.13 No. 4 p.327 ~ p.332
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Screening of ten medicinal plants of Bangladesh for analgesic activity on Swiss-albino mice
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Sikder M. A. A.
Rashid R. B.
Islam F.
Hossian A. K. M. N.
Siddique A. B.
Kabir S.
Haque M. R.
Rahman M. S.
Rashid M. A.
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Abstract
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Bangladesh is a good repository of medicinal plants, which contribute a lot to the healthcare management of the local people. In order to explore the pain-relieving potentiality of some indigenous plants of Bangladesh, ten plants were selected initially and screened out for analgesic activity. For this case, plants were extracted with 95 % methanol and then assayed by acetic acid-induced writhing and tail immersion methods for peripheral analgesic action and by formalin-induced pain method for central analgesic action in Swiss-albino mice model. Plant extracts were orally administered to the mice at 400 mg/kg body weight for this evaluation. In this study, Justicia gendarussa, Musaenda philippica, Steudnera virosa, Trewia polycarpa, Hydnocarpus kurzii and Nymphaea nouchali might be considered as promising analgesic candidate among the tested plants.
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KEYWORD
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AnalgesicAcetic acidFormaldehydeHeat stimuliWrithingFlickingPaw licking
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