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KMID : 1200820140140020103
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 2 p.103 ~ p.109
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In vivo evaluation of cutaneous wound healing activity of Mirabilis jalapa L radix
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Gogoi Jyotchna
Nakhuru Khonamai Sewa
Chattophadhayay Pronobesh
Rai Ashok Kumar
Gogoi Hemanta Kumar
Veer Vijay
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Abstract
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The present study was to evaluate in vivo cutaneous wound healing activity of hydromethanolic extract of M. jalapa radix and to validate its traditional use as medicine for wound healing. In excision wound model, the wound area was measured on the day of infliction (zero day) and subsequently at 4 days interval until the completion of wound healing. In dead space wound model, on 10th post wounding day, the granulation tissues were harvested for estimation of blotting of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF 2) and collagen type III (COL 3A), hydroxyproline content and histological studies. A significant increase (p?
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KEYWORD
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Epithelialisation period, Granulation, Hydroxyproline, Mirabilis jalapa L, Wound healing
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