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KMID : 1200820140140020145
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 2 p.145 ~ p.155
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Antiulcer and antioxidant effects of Normacid syrup (a polyherbal formulation) on experimentally-induced gastric ulcers
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Maheshwari Rajesh
Balaraman R.
Sailor Girish
Parmar Ghanshyam
Patel Anjal
Seth A. K.
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Abstract
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The aim of this work was to study the antioxidant and antiulcer activities of Normacid syrup® (NS) in mice. Effects of NS (250 and 500 mg/kg, p.o., for 14 days) were studied on pylorus ligation and diclofenac-induced ulcers. Antiulcer activity of NS was assessed from gastric secretion parameters, mucosal nitrite level and mucin content in gastric mucosa. The activity of antioxidant enzymes like super oxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and lipid peroxidation (MDA) in the stomach tissue were quantified. Histopathological studies were done on stomach tissues. Pre-treatment with NS significantly (p?
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KEYWORD
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Pylorus ligation, Diclofenac, Ayurvedic formulation, Antiulcer
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