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KMID : 1200820140140020163
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 2 p.163 ~ p.167
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Evaluation of lyophilized extract of leaves of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain
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Sawant Sudarshan
Chine Virendra
Kalange Annasaheb
Joshi Parag
Gawali Vaibhavkumar
Praharaj Shuvranshu Narayan
Jangme Chandraprabhu
Siddiqui Masood
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Abstract
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The aim of present study was to evaluate effect of lyophilized extract of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain. The antiallodynic and antihyperalgesic activity of Tridax procumbens was assessed in Chronic Constriction Injury of Sciatic Nerve in rats (CCI) and Scald pain model in rats (burning pain) respectively at 100,200 and 400 mg/kg, p.o. In CCI model, the extract shows the dose dependent antiallodynic activity 60 min. post dose. In Scald pain model, extract shows the significant antihyperalgesic activity at 200 and 400 mg/kg at 60 and 90 min. post dose. The lyophilized extract of Tridax procumbens was found to be effective in neuropathic and inflammatory pain, suggesting its possible action via peripheral mechanisms. The activity may be attributed to the presence of flavonoids such as Quercetin.
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KEYWORD
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Tridax procumbens, Quercetin, Chronic constriction injury, Scald pain, Neuropathic pain, Inflammatory pain, Lyophilization
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