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KMID : 1200820140140020169
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 2 p.169 ~ p.180
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Pharmacological evaluation of Chlorophytum borivilianum Sant. & Fern. for anxiolytic activity and effect on brain GABA level
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Swami Uma S.
Lande Aniruddha A.
Ghadge Prachi M.
Adkar Prafulla P.
Ambavade Shirishkumar D.
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Abstract
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The present study was performed to investigate anxiolytic activity of aqueous extract of roots of Chlorophytum borivilianum Sant. & Fern. and effect on brain GABA level. The anxiolytic activity of the aqueous extract (20, 60 and 200 mg/kg) was evaluated in mice. Extract was administered intra-peritoneally (Acute treatment) or orally (14 days repeated dose study). The elevated plus maze test (EPM), open field test (OFT), light and dark test (L/D), actophotometer and rotarod were used to evaluate exploratory, sedative and muscle relaxant activities in mice respectively and level of GABA was determined in mice brain. Acute treatment with aqueous extract of roots of C. borivilianum 60 and 200 mg/kg i.p increased time spent and entries in open arm of EPM, increased number of square travelled at center in OFT, increased time spent and entries in light area in L/D model. In chronic study 60 and 200 mg/kg p.o showed anxiolytic activity whereas 60 mg/kg p.o is more persistent and prominent. Chronic administration did not produced tolerance to the anxiolytic activity. GABA level in mice brain was not changed after treatment with 60 and 200 mg/kg of extract indicating drug may act through other mechanism like serotonergic or adrenergic system. Result of present study justifies the use of Chlorophytum borivilianum Sant. & Fern. in traditional medicine for the management of anxiety. Aqueous extract showed significant anxiolytic activity at 60 mg/kg and 200 after acute and chronic treatment without sedative effect.
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KEYWORD
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Anxiolytic, Chlorophytum borivilianum, Elevated plus maze, GABA, Behavioral models
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