|
KMID : 1200820140140030231
|
|
Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 3 p.231 ~ p.236
|
|
|
Antioxidant and antiparkinsonian activity of Passiflora incarnata leaves
|
|
Ingale Suvarna P.
Kasture Sanjay B.
|
|
|
Abstract
|
|
|
|
Herbal remedies for human brain disorders are much preferred over synthetic drugs because of various side effects of synthetic drugs ranging from sleep disorders to withdrawal syndromes. Passiflora incarnata Linn (Passifloraceae) has been widely used in traditional medicine in West India, Mexico, the Netherlands, and South America. It has been used as an anxiolytic and sedative-hypnotic since ancient times. The main constituents of leaves of P. incarnata are flavonoid and indole alkaloids based on β -carboline ring system viz., harman, harmine, harmalol and harmaline. Harmine and harmaline alkaloids are reported to be effective antiparkinsonian compounds. The objective of present investigation was to evaluate antiparkinsonian activity and antioxidant activity of butanol extract of P. incarnata leaves (BEPI). Antiparkinsonian activity of BEPI was studied using haloperidol induced catalepsy and tacrine induced jaw movements. The antioxidant activity of BEPI was studied using DPPH scavenging assay and H2O2 scavenging assay. The results of present study has shown that butanol extract of P. incarnata leaves (BEPI) (150 mg kg?1 and 300 mg kg?1, i.p.) significantly (p?≤?0.001) reduced the duration of haloperidol induced catalepsy as well as tacrine induced jaw movements. BEPI has also shown significant antioxidant effect. The result obtained in current study indicates that BEPI posses antiparkinsonian as well as antioxidant activity which may be useful in symptomatic relief of PD and to prevent progression of PD.
|
|
|
KEYWORD
|
|
|
Antioxidant activity, Antiparkinsonian activity, DPPH scavenging activity, Haloperidol, Tacrine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|