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KMID : 1200820140140030237
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 3 p.237 ~ p.243
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Oral administration of betaine ameliorates ethanol-induced gastric injury in rats through its antioxidant effects
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Ahn Mee-Jung
Kang Yoon-Hyoung
Moon Ji-Hwan
Kim Seung-Joon
Moon Chang-Jong
Shin Tae-Kyun
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Abstract
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The aim of this study was to evaluate whether betaine ameliorates ethanol-induced gastric injury in rats. The morphological, histological and biochemical characteristics of gastric hemorrhagic lesions in ethanol-injured rats (n?=?5/group) pretreated with betaine were analyzed and compared to non-treated controls. We compared the hemorrhagic dimensions using the Image J software, lipid peroxidation by malondialdehyde (MDA) concentration and inducible nitric oxide synthase (iNOS) immunoreactivity in the gastric mucosa among treatment groups. Oral administration of 250 mg/kg betaine significantly reduced gastric hemorrhage dimensions compared with the vehicle-treated control (p <0.05). Immunohistochemical analysis showed that the expression of iNOS and its byproduct nitrotyrosine were significantly reduced in betaine-pretreated rats compared to vehicle-treated rats with ethanol injury (p?
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KEYWORD
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Betaine, Ethanol, Gastric injury, Gastroprotection, Rat
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