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KMID : 1200820140140040369
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Oriental Pharmacy and Experimental Medicine
2014 Volume.14 No. 4 p.369 ~ p.374
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Alleviation of the hepatotoxic effect of bromobenzene by the Indian traditional herbal formulation Triphala in experimental rats
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Baskaran Udhaya Lavinya
Rasool Mahaboobkhan
Sabina Evan Prince
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Abstract
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The present study is an attempt to investigate the efficacy of Triphala in ameliorating the hepatotoxic effects of bromobenzene (BB) in experimental rats. Hepatotoxicity was induced in rats by oral administration of BB (1.57 mg/kg b.w.) and Triphala was given orally at two doses of 250 and 500 mg/kg b.w. for a period of 8 days. The antioxidant status was studied by measuring lipid peroxidation, total reduced glutathione levels and enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in liver tissue homogenates. In addition, the levels of cytokines such as tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured in serum. The hepatoprotective role of Triphala was compared with that of the standard hepatoprotective agent silymarin. The treatment of BB-intoxicated rats with Triphala showed significant (p?
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KEYWORD
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Hepatotoxicity, Bromobenzene, Antioxidant, Cytokines, Triphala
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