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KMID : 1200820150150020123
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Oriental Pharmacy and Experimental Medicine
2015 Volume.15 No. 2 p.123 ~ p.134
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Inhibitory effects of Anthocephalus cadamba stem bark fractions intercede anti-inflammatory and carbon tetrachloride induced hepatotoxicity in rats
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Dolai Narayan
kumari Uma
Islam Aminul
Haldar Pallab Kanti
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Abstract
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Anthocephalus cadamba (Roxb.) Miq. (Rubiaceae) is commonly known as “Kadamba”, frequently found in moist deciduous evergreen forests. The present study was performed to evaluate the anti-inflammatory and hepatoprotective potential of A. cadamba fractions in relation to the free radical scavenging properties to corroborate and establish scientific evidence for its ethno-botanical uses. Quantification assay were determined for total phenolic and flavonoid compounds. Free radical scavenging properties were assessed by 1, 1-Diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide, peroxynitrite, superoxide, hypochlorous acid scavenging methods. Protein denaturation and human red blood cell membrane stabilization methods were performed to determine anti-inflammatory activity. Furthermore, Hepatocuretive potential was evaluated using carbon tetrachloride intoxicated (CCl4) rat’s model. Methanol fraction of A. cadamba (MEAC) was found to be the most potent free radical scavenger in all in vitro models. The higher inhibition properties of MEAC positively correlated with total phenolic (164.75?±?3.83 mg GAE/g) and flavonoid compounds (51.20?±?2.15 mg QE/g). The MEAC showed significant (p?
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KEYWORD
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Anthocephalus cadamba, Antioxidant, Anti-inflammatory, Hepatocurative
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