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KMID : 1200820150150020135
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Oriental Pharmacy and Experimental Medicine
2015 Volume.15 No. 2 p.135 ~ p.140
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In vitro antimicrobial activity study and in vivo antiemetic, antinociceptive activity evaluation of leaves extract of Erioglossum rubiginosum using experimental animal model
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Sajib Amirul Islam
Dewan Syed Masudur Rahman
Das Abhijit
Sarwar Shahid
Sarkar Rakhesh Chandra
Ahmed Maizbha Uddin
Islam Mohammad Safiqul
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Abstract
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The present study explored the phytochemical screening, in vitro antimicrobial activity, in vivo antiemetic and antinociceptive potentialities of methanol extract of Erioglossum rubiginosum leaves for the first time. Crude extract of E. rubiginosum and different fractions were assayed for in vitro antimicrobial activity using disc diffusion method. The antiemetic activity was evaluated using chick emesis model; while acetic acid induced writhing test in mice was conducted to determine the antinociceptive activity. Different extracts possess carbohydrate, flavonoids, saponin, tannin, alkaloids, phenol and cardiac-glycoside in varying concentrations. Among different extractives, only the chloroform soluble fraction showed promising antimicrobial activity (zone of inhibition 6.5 to 10 mm) in comparison to positive control?ciprofloxacin, against wide range of tested microorganisms. In antiemetic assay, all the extracts showed significant (P?
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KEYWORD
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Antiemetic, Antimicrobial activity, Antinociceptive, Erioglossum rubiginosum, Phytochemical, Sapindaceae
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