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KMID : 1200820150150030191
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Oriental Pharmacy and Experimental Medicine
2015 Volume.15 No. 3 p.191 ~ p.198
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Effect of Bauhinia variegata Linn. (Caesalpiniaceae) extract in streptozotocin induced type I diabetic rats
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Kulkarni Yogesh Anant
Garud Mayuresh Sudamrao
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Abstract
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Bauhinia variegata Linn. (Caesalpiniaceae), also known as ‘Kanchnar’, is an important medicinal plant mentioned in Ayurveda. In present study, we evaluated the effect of alcoholic extract of leaves of B. variegata in streptozotocin (STZ) induced type 1 diabetes. Diabetes was induced in male Sprague Dawley rats by using STZ (55 mg/kg, i.p). Diabetic animals were orally administered with alcoholic extract (AlcE) of B. variegata at dose of 250, 500 and 1000 mg/kg body weight for 4 weeks. Glipizide (5 mg/kg) was used as standard drug. Biochemical parameters analysis, Oral glucose tolerance test (OGTT) and histopathological studies were carried out at the end. The percent decrease in plasma glucose level was 22.67 %, 29.32 % and 41.78 % respectively for groups treated with AlcE 500 and 1000 mg/kg and glipizide. Body weight was increased after treatment with AlcE at dose of 500 and 1000 mg/kg. In OGTT, AlcE showed improvement in glucose tolerance. AlcE had also significantly lowered the cholesterol, triglyceride, creatinine, BUN and increased the total protein and albumin level at dose of 500 and 1000 mg/kg. Histological analysis showed that AlcE have protective effect on pancreatic cells. Alcoholic extract of Bauhinia variegata showed significant antidiabetic effect in STZ induced type 1 diabetes.
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KEYWORD
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Alcoholic extract, Kanchnar, Oral glucose tolerance test, Pancreas
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