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KMID : 1200820150150040277
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Oriental Pharmacy and Experimental Medicine
2015 Volume.15 No. 4 p.277 ~ p.285
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Evaluation of antacid capacity and antiulcer activity of Calendula officinalis L. in experimental rats
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Chandra Phool
Kishore Kamal
Ghosh Ashoke Kumar
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Abstract
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Calendula officinalis has been traditionally used in India for treating wounds, ulcers, herpes, scars, skin damage, frostbite and blood purification. Present study was aimed to evaluate antacid capacity in-vitro and antiulcer activity of extract from Calendula officinalis L. (family: Asteraceae) in experimental rats. Evaluation of ethanol extract (100 and 200 mg/kg, orally) from Calendula officinalis (ECO) as antisecretory and in-vivo antacid capacity were carried out by pyloric ligation induced ulcer model. The gastroprotective effect was carried out by absolute ethanol induced ulcer and indomethacin induced ulcer model. Integrity of gastric mucosa was evaluated by the estimation of glutathione (GSH) and gastric mucus level. The in-vitro antacid capacity was evaluated by titration method. ECO produced significant inhibition of ulcer index in all models of ulcers and comparable to standard. The in- vitro antacid capacity was found as 20.58?±?0.08 mEq/g of ECO. The total protein and pepsin level were found as 92.45?±?1.89 μg/ml and 34.67?±?1.25 μmole/ml, respectively in pylorus ligation model at 200 mg/kg of ECO. GSH level were significant elevated by 200 mg/kg of ECO (P?
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KEYWORD
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Calendula officinalis, Pylorus ligation, Indomethacin induced ulcer, Ethanol induced ulcer
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