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KMID : 1200820150150040341
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Oriental Pharmacy and Experimental Medicine
2015 Volume.15 No. 4 p.341 ~ p.346
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Bronchodilatory activity of Curcuma longa, Zingiber officinale and Alpinia galanga based herbal formulation (AHF)
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Dongre Priti R.
Bhujbal Santosh S.
Kumar Dinesh
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Abstract
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Curcuma longa, Zingiber officinale and Alpinia galanga are traditionally and scientifically reported for the treatment of respiratory disorders such as asthma, bronchial congestion and allergic reactions in respiratory tract. As part of a continuing effort aimed at the development of efficacious bronchodilator and anticataleptic herbal formulation for the treatment of asthma and related respiratory diseases. We have formulated herbal capsules (AHF) using Curcuma longa, Zingiber officinale and Alpinia galanga extracts. In this report, we have focused on the evaluation of AHF for bronchodilatory potential. AHF was studied on clonidine induced mast cell degranulation and OVA albumin induced airway inflammation model at the doses of 62.5,125 and 250 mg/kg. AHF at dose of 250 mg/kg showed significant protection of mast cell degranulation (40%) as compared to standard sodium cromoglycate (64%) while at doses of 62.5, 125, 250 mg/kg showed marked inhibition of total cells, eosinophils, neutrophils, lymphocytes, whereas in case of macrophages and monocytes an inhibition was observed at 125, 250 mg/kg along with the inhibition of IgE. The findings revealed that the bronchodilatory activity of AHF may be due to the mast cell stabilizing potential, suppression of IgE, and inhibition of release of inflammatory mediators.
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KEYWORD
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Asthma, Anticataleptic activity, Bronchodilatory activity, Mast cell, Airway inflammation, Herbal formulation
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