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KMID : 1200820170170020143
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Oriental Pharmacy and Experimental Medicine
2017 Volume.17 No. 2 p.143 ~ p.150
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Assessment of the cytotoxic activity and the reduction power of Limoniastrum feei Girard (Batt.): a medicinal plant from Algerian Sahara
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El Haci Imad Abdelhamid
Mazari Wissame
Atik Bekkara Fawzia
Hassani Faycal
Gherib Mohamed
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Abstract
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This scientific work involves a phytochemical study of a medicinal plant endemic to the south of Algeria: Limoniatrum feei Girard (Batt.). The study of the antioxidant effects and the evaluation of the cytotoxicity were reported. Polar organic extracts: methanol, ethanol and acetone of L. feei presented considerable levels of phenols and flavonoids. These levels were ranged from 127.07 to 262.11 mg GAE/g and 84 to 157.88 mg CEQ/g, respectively. Considerable antioxidant activity of polar organic extracts of L. feei was revealed. In the DPPH scavenging method, methanolic extract expressed an IC50 of about 3.2 μg/mL which is comparable to that of the ascorbic acid (2.48 μg/mL). The same extract expressed strong antioxidant power against hydroxyl radical with an IC50 of about 36.33 μg/mL, which is higher than that of the ascorbic acid (61.83 μg/mL). In the test of the β-carotene bleaching, acetone extract expressed a remarkable antioxidant power comparable to the positive control (IC50: 5.85 μg/mL and 4.26 μg/mL, respectively). A low cytotoxic activity against human red blood cells was exerced by the methanol extract of L. feei, this could explaine the safety uses of this plant by indigenous populations.
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KEYWORD
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Endemic medicinal plant, Limoniastrum feei, Biological activities, Organic extracts, Phenolic compounds
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