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KMID : 1200820170170020161
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Oriental Pharmacy and Experimental Medicine
2017 Volume.17 No. 2 p.161 ~ p.169
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Preclinical evaluation of Kali Haldi (Curcuma caesia): a promising herb to treat type-2 diabetes
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Majumder Poulami
Mazumder Suchandra
Chakraborty Mainak
Chowdhury Srila Ghosh
Karmakar Samit
Haldar Pallab Kanti
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Abstract
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The methanol extract of Curcuma caesia (MECC) rhizome showed antidiabetic activity by lowering blood glucose in in vivo studies and controlled intestinal absorption of monosaccharides by inhibiting alpha amylase and alpha glucosidase. It also enhanced the glucose uptake in yeast cells, proving proper glucose utilization. The IC50 values of MECC were found to be 442.92 ± 10.05 μg/ml and 95.40 ± 9.74 μg/ml in alpha amylase and alpha glucosidase inhibition respectively. The extract has effective antioxidant activities, by successfully scavenging free radicals like superoxide and hydroxyl ions. The histopathological studies of pancreas showed gradual healing after treatment.
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KEYWORD
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Antidiabetic, Alpha amylase, Alpha glucosidase, Glucose uptake, Antioxidants
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