KMID : 1200820170170030255
|
|
Oriental Pharmacy and Experimental Medicine 2017 Volume.17 No. 3 p.255 ~ p.268
|
|
Protective effects of the Sophorae Fructus on cognitive impairment and neuroinflammatory alteration in an A¥â1-42-infused Alzheimer¡¯s disease mouse model
|
|
Lee Hwa-Young
Kwon Yong-Ju Cho Seung-Hun
|
|
Abstract
|
|
|
Alzheimer¡¯s disease (AD), a common cause of neuropsychological impairment, is characterized by the deposition of a neurotoxic and fibrillogenic form of the ¥â-amyloid (A¥â) peptide, A¥â1?42. The present study showed the therapeutic efficacy of Sophorae Fructu (KH034) on A¥â1?42-infused memory dysfunction in mice. KH034 treatment significantly recuperated deficit in learning and memory of the A¥â1?42 ?infused mice, as determined by Y-maze and Morris water maze test. Through biochemical analysis test, we suggested that KH034 treatment ameliorated A¥â accumulation and neuronal cell death in the cortex and hippocampus of the mice brain. Furthermore, KH034 treatment enhanced neuron-specific nuclear protein (NeuN) and brain derived neurotrophic factor (BDNF) levels. Moreover, KH034 treatment activated the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) in the hippocampus. Thus, KH034 treatment inhibited the activity of proteins associated with neurodegeneration in AD through its anti-amyloidogenic, anti-inflammatory and pro-survival effect. These results suggest that KH034 treatment improves cognitive function and inhibits amyloidogenesis by the prevention of neuroinflammation in A¥â1?42 ?infused mice. Therefore, KH034 may be useful in the prevention and treatment of neurodegenerative disorders such as Alzheimer¡¯s disease.
|
|
KEYWORD
|
|
Sophorae Fructus, Alzheimer¡¯s disease (AD), Beta amyloid (A¥â), Cognitive impairment, Neuroinflammation
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|