KMID : 1200820180180020139
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Oriental Pharmacy and Experimental Medicine 2018 Volume.18 No. 2 p.139 ~ p.147
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Analgesic and anti-inflammatory activities of methanolic extract of Mallotus repandus stem in animal models
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Hasan Md. Rakib
Uddin Nizam Sana Tanmoy Hossain Md. Monir Mondal Milon Kanta Ismat Jarin Choudhuri M. S. K.
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Abstract
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The aim of our current study is to investigate the analgesic and anti-inflammatory potentials of methanolic extract of Mallotus repandus stem (MSM) using different in vivo assay models. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, tail immersion method, hot-plate test, formalin induced hind paw licking, xylene induced ear edema, carrageenan-induced paw edema and cotton pellet induced granuloma in animal model at doses of 500, 1000 and 2000 mg/kg body weight. MSM showed significant (p?0.05) analgesic activities in the acetic acid-induced writhing tests in mice. In the tail immersion and hot-plate test, MSM significantly prolonged the latency period (p?0.05). Significant (p?0.05) formalin induced paw licking inhibition was observed at different doses and the highest 74.47% inhibition was observed at 2000 mg/kg. Besides, MSM showed significant (p?0.05) anti-inflammatory responses in carrageenan induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. These findings suggest that the plant may be a potential source for the development of new analgesic and anti-inflammatory agent.
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KEYWORD
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Mallotus repandus, Anti-inflammatory, Analgesic, Carrageenan, Tail immersion
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