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KMID : 1200820180180030177
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Oriental Pharmacy and Experimental Medicine
2018 Volume.18 No. 3 p.177 ~ p.186
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The role of medicinal plants and natural products in melioration of cadmium toxicity
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Bhattacharya Sanjib
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Abstract
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Cadmium is extremely toxic heavy metal and there is no specific, safe and efficacious therapeutic management of cadmium toxicity. Scientific literature reveals several medicinal plants and natural products alleviate experimentally induced cadmium toxicity in animals. The present review attempts to collate those experimental studies on medicinal plants and plant derived natural products with cadmium toxicity ameliorative effects. Literature survey was carried out by using internet and the studies for the last two decades were considered. Minerals and semi-synthetic or synthetic analogs of natural products were excluded. Literature study revealed that 36 medicinal plants and 16 natural products exhibited significant protection from cadmium toxicity in experimental animal models i.e., pre-clinical studies. Clinical studies were not found in literature. Relevant research in this field could lead to development of a potentially useful agent in therapeutic management of cadmium toxicity in humans.
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KEYWORD
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Cadmium, Ascorbic acid, Natural products, Oxidative stress, Quercetin
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