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KMID : 1200820180180030209
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Oriental Pharmacy and Experimental Medicine
2018 Volume.18 No. 3 p.209 ~ p.215
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Efficacy of snakehead fish (Channa striatus) in subjects with allergic rhinitis: a randomized controlled trial
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Susibalan Bathma Dhevi
Abdullah Baharudin
Lazim Norhafiza Mat
Kadir Azidah Abdul
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Abstract
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Allergic rhinitis is a prevailing chronic inflammatory respiratory disorder that affects 10?30% of the population globally. Channa striatus (Channa) is a snakehead, freshwater fish that has been used traditionally to enhance wound healing and relief post-operative pain. This study evaluates the efficacy of oral Channa extract on allergic rhinitis subjects on total nasal symptom score and serum immunoglobulin E (Ig E). A randomized, double-blind, placebo-controlled trial was conducted by comparing the oral Channa extract 500 mg/day and placebo among allergic rhinitis subjects for a 6-week intervention period. Subjects aged 18?50 years old, diagnosed with allergic rhinitis based on total symptoms score, naso-endoscopy findings, and positive skin prick test were included in this trial. All subjects were treated with antihistamine (levocetrizine) and local corticosteroid nasal spray (fluticasone furoate nasal spray). Laboratory-based blood tests were used as safety measures. A total of 70 subjects were randomized. Channa group showed significant improvement in nasal blockage (p?
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KEYWORD
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Allergic rhinitis, Channa striatus, Immunoglobulin E, Nasal symptoms score
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