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KMID : 1200820180180040281
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Oriental Pharmacy and Experimental Medicine
2018 Volume.18 No. 4 p.281 ~ p.298
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Focalization of thrombosis and therapeutic perspectives: a memoir
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Keziah S. Merlyn
Devi C. Subathra
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Abstract
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The main aim of the review is to recapitulate the effects of thrombotic diseases, clotting disorders, and the methodology of prospecting a range of thrombolytics from various sources and thrombolytic therapies. Thrombolytic medications are administered to infringe dangerous clots inside blood vessels when there is deprivation in this haemostatic balance. Certain bioactive compounds present in herbs, plant leaves, roots and fruits exhibit thrombolytic activities. Serine proteases, metalloproteases and some cysteine proteases possess thrombolytic properties. These proteases are found in plants, humans, animals and microbes as well. Thrombolytics which are of clinical importance are discussed in this article along with its variants and biological sources exhibiting thrombolytic activity. Alternative therapies followed in recent days are also discussed, including future prospects of research on thrombolytics. Knowledge of thrombolytic biodiversity plays a decisive role in choosing safe, economic and effective thrombolytics for scale up and commercialization.
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KEYWORD
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Thrombosis, Thrombotic diseases, Clot busters, Alternative therapies
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