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KMID : 1200820190190010037
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 1 p.37 ~ p.47
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Comparative study of anti-allergic activity of two poly-herbal formulations in ova-challenged allergic rhinitis mice model
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Srivastava Richa
Srivastava Sajal
Singh Satya Prakash
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Abstract
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This study was to prepare a novel in situ gel system for nasal delivery of poly-herbal extracts and study its efficacy on the allergic rhinitis model. The main purpose is to compare the efficacy of poly-herbal nasal drops and in situ gel. A temperature depended in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40?±?2 °C for 6 months, and the micrographic results showed that in situ gel was safety without mucous irritation when given daily for 26 days to mice with allergic rhinitis that the effect of drops for the treatment. Extracts in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 g/body following intranasal administration, and the efficacy was significantly superior to that of the drops (p?
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KEYWORD
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Moringa olifera, Embelia ribes, Gellan gum, Pluronics, In-situ, Allergic rhinitis, Polyherbal
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