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KMID : 1200820190190010049
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 1 p.49 ~ p.58
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The effect of Elsholtzia densa methanolic extract modulates inflammation in vitro and in vivo
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Zargar Ovais Ahmad
Bashir Rohina
Ganie Showkat Ahmad
Hamid Rabia
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Abstract
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Inflammatory diseases being one of the back bending global burden are alarming the world. Established anti-inflammatory drugs exert side-effects, demanding for the development of alternative drugs, likely from natural source because of their diverse chemical nature. The anti-inflammatory activity of aerial part methanol extract of Elsholtzia densa collected from the natural forest of Naranag area of Kashmir valley was evaluated both in vitro and in vivo model systems using Macrophages RAW 264.7 cells and acute (carrageenan and histamine-induced rat paw edema) and chronic model (formaldehyde induced arthritis) respectively. The EDM extract exhibited a significant decline in the paw volume being at par with the standard drug Diclofenac (10 mg/kg) as compared with the control group. The reduction was observed in dose dependent manner with 300 mg/kg resulting in 27.27% and 100 mg/kg in 16.88% inhibition at 3rd h. A statistically significant (p?
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KEYWORD
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Elsholtzia densa, RAW264.7, Carrageenan, Diclofenac, Cytokine, Arthritis
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