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KMID : 1200820190190010091
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 1 p.91 ~ p.106
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Phytochemical screening and evaluation of the pharmacological activities of ethanolic extract of Argemone mexicana Linn. aerial parts
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Sarkar Kishore Kumar
Mitra Trina
Acharyya Rabindra Nath
Sadhu Samir Kumar
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Abstract
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The present study was designed to investigate different phytochemical groups present in ethanolic extract of Argemone mexicana aerial parts (EAMA) as well as to assess the analgesic, antidiarrheal, antibacterial, anthelmintic and cytotoxic activities of EAMA. Moreover, peripheral and central analgesic activities were evaluated by acetic acid-induced writhing test, formalin-induced paw licking test, tail immersion test and hot plate test. In vivo castor oil-induced diarrheal model and magnesium sulphate induced diarrheal model in mice were utilized for the assessment of antidiarrheal activity. Again, antibacterial activity was evaluated using disc diffusion assay. Anthelmintic activity was carried out on Paramphistomum cervi (Trematoda). Cytotoxic activity was assessed through brine shrimp lethality bioassay. The extract demonstrated the presence of alkaloids, flavonoids, phenolic compounds, tannins, glycosides and gums in phytochemical screening. In case of acetic acid-induced writhing and formalin induced paw licking test, both lower and higher doses of EAMA showed significant percentage inhibition of writhing as well as paw licking respectively (*P?
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KEYWORD
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Argemone mexicana, Analgesic, Antidiarrheal, Antibacterial, Anthelmintic, Cytotoxic
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