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KMID : 1200820190190010107
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 1 p.107 ~ p.114
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Gene expression profile of PM014 of immortalized mouse lung epithelial cells in response to the effect of PM014 on radiation-induced fibrosis
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Shin Da-Som
Joo Kyung-Goo
Kang Mi-Jung
Pak Se-Hyun
Kim Youn-Sub
Bae Hyun-Su
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Abstract
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Radiotherapy is a major method for cancer treatment, but it frequently causes various side effects such as radiation-induced pneumonia and pulmonary fibrosis. Drugs to treat these side effects are urgently needed in the clinic, since there is no clearly defined medication for treating these symptoms. Previous studies demonstrated that the herbal formula, PM014, is effective for radiation-induced lung injury and fibrosis in mice. In this study, we investigated gene expression profiles to understand the mechanism of action behind the effects of PM014 on radiation induced damage in immortalized lung epithelial cells, MLE12. We performed QuantSeq 3′ mRNA-Seq analysis on the mRNA from radiation treated MLE-12 cells in the presence and absence of PM014. Transcriptome analysis found that 217 genes were significantly affected by PM014. Among them (217 genes, >?twofold, p value
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KEYWORD
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MLE-12, PM014, Irradiation, Inflammation
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