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KMID : 1200820190190040435
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 4 p.435 ~ p.444
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Pre-clinical investigation of anti-diarrheal and CNS depressant effect of Wedelia trilobata in Swiss albino mice
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Islam Md. Al Foyjul
Barua Anindya
Binoy Maksud Hassan
Alam Md. Jahir
Ershad Md.
Choudhuri M. S. K.
Masuma Runa
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Abstract
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Wedelia trilobata (WT) has been used in folk medicine to alleviate several diseases such as cough, cold, flu, fever and inflammation. The study was investigated to evaluate anti-diarrheal and CNS effect of ethanolic extract of W. trilobata in mice. Anti-diarrheal effect was evaluated using castor oil and MgSO4 induced diarrhea tests in mice. Gastrointestinal motility was measured using BaSO4. CNS effect was investigated using hole board, hole cross and elevated plus maze tests. Extract was used at dose of 1000 mg/kg and 2000 mg/kg body weight. Loperamide (10 mg/kg per oral) and diazepam (4 mg/kg) were used as standard drug. The crude extract exhibited significant anti-diarrheal effect in the total number of feces and episodes of diarrheal feces. Treatment with WT at both the doses, very highly reduced diarrhea significantly (p?
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KEYWORD
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Wedelia trilobata, Antidiarrheal effect, Castor oil and MgSO4 induced diarrhea, BaSO4 induced GI motility, CNS depressant effect
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