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KMID : 1200820190190040497
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 4 p.497 ~ p.507
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Effect of combination of Tribulus terrestris, Boerhavia diffusa and Terminalia chebula reverses mercuric chloride-induced nephrotoxicity and renal accumulation of mercury in rat
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Yadav Harlokesh Narayan
Sharma Uma Shankar
Singh Surender
Gupta Yogendra Kumar
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Abstract
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Mercury generates free radicals and oxidative stress which are associated with renal injury. Tribulus terrestris (TT), Boerhavia diffusa (BD), and Terminalia chebula (TC) have anti-inflammatory and antioxidant properties. Hydroalcoholic extract of combination of TT, BD and TC were evaluated against mercuric chloride induced nephrotoxicity. Rats (n?=?6) were treated with combination of TT, BD and TC in three different doses (198, 300 and 600 mg/kg) of equal ratio of each drug and Combination per se. Drugs were administered orally for period of 7 days. Nephrotoxicity was induced by single dose of mercuric chloride (5 mg/kg, i.p.) on fifth day. Combination of above drugs at all three doses significantly (p?
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KEYWORD
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Mercuric chloride, Nephrotoxicity, Plant extract, Antioxidant, L-FAB, KIM-1
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