|
KMID : 1200820200200010035
|
|
Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 1 p.35 ~ p.52
|
|
|
Leea macrophylla (Roxb.) root extract reverses CCl4 induced liver injury through upregulation of antioxidative gene expression: a molecular interaction for therapeutic inception
|
|
Bulbul Md. Rakibul Hassan
Rahman Md. Atiar
Rahman Md. Zillur
Emran Talha Bin
Afroze Mirola
Khan Mala
Chowdhury Muhammad Abid Hasan
Ibrahim Mohammed Auwal
Chowdhury Mohammed Sohel
|
|
|
Abstract
|
|
|
|
This study investigated the restorative effect of Leea macrophylla ethanol root extract (LMERE) in carbon tetrachloride (CCl4) induced hepatic injury. It also tried to unfold the underlying mechanism through ligand-receptor interactions. Prior to conduct the CCl4 induced animal model study, the in vitro antioxidative capacities of LMERE were investigated. Gas chromatography mass spectroscopy (GC?MS) was accomplished to identify the prevalent bioactive compounds. The molecular docking was performed using Schrodinger Suites 2017-1. Results showed the promising antioxidative potentials of LMERE in in vitro models. Upon treatment of CCl4 intoxicated animals with LMERE, serum ALT and AST were found to be significantly (p?
|
|
|
KEYWORD
|
|
|
Leea macrophylla, Root extract, Hepatoprotective, Histopathological scoring, Catalase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|