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KMID : 1200820200200010053
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 1 p.53 ~ p.59
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Antifibrotic effects of fermented black radish (Raphanus sativus L. var. niger) on chronic liver injury in rats
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Kim Jeong-Tae
Ahn Mee-Jung
Choi Yu-Na
Ekanayake Poornima
Kim Gi-Ok
Shin Tae-Kyun
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Abstract
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We evaluated the antifibrotic effects of fermented black radish (FBR) on carbon tetrachloride (CCl4)-induced chronic liver injury in rats. Serum biochemical analysis indicated that FBR treatment attenuated the upregulation of alanine aminotransferase and aspartate aminotransferase. Moreover, Sirius red staining and histopathological examination revealed decreased fibrosis and inflammation in FBR-treated rats compared with CCl4?+?vehicle-treated rats. Western blot analysis of alpha-smooth muscle actin expression levels confirmed the downregulation of fibrosis in the FBR treatment group compared with the CCl4?+?vehicle treatment group. These results suggest that FBR treatment suppressed liver fibrosis in CCl4-exposed rats.
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KEYWORD
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Carbon tetrachloride, Chronic injury, Fermented black radish, Fibrosis, Liver
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