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KMID : 1200820200200020243
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 2 p.243 ~ p.253
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Protective action of Grewia asiatica (phalsa) berries against scopolamine-induced deficit in learning and memory using behavior paradigms in rats
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Paul Sangeeta
Sharma Swapnil
Paliwal Sarvesh Kumar
Kasture S. B.
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Abstract
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Grewia asiatica L. (family-Malvaceae) commonly known as phalsa has been used traditionally as Rasayana which has a role in ameliorating cognitive decline and has a stimulant effect. The present study was conducted with an aim to investigate whether G. asiatica berries ameliorates cognitive deficits induced by scopolamine. In this experimental work, cognition enhancement activity of G. asiatica extracts (200 mg/kg) was assessed against scopolamine-induced amnesia using elevated plus maze model. To assess the protective potential of G. asiatica on scopolamine-induced damages effect on acetylcholinesterase (AChE), lipid peroxidase and superoxide dismutase, contents were estimated in rat brain homogenate spectrophotometrically and histopathological studies were done. Effect of methanol extract of G. asiatica (200 and 400 mg/kg) was assessed on dopamine and serotonin-mediated behavior using haloperidol-induced catalepsy and lithium-induced head twitches model respectively. Results showed that methanol extract of G. asiatica caused restoration of memory caused due to scopolamine-induced amnesia as measured on behavioral paradigms by elevating neurotransmitter acetylcholine, amelioration of oxidative stress markers, restoration of damaged neuronal cells cytoarchitecture and modulation of monoamines mediated behavior eliciting role of phalsa as promising nootropic candidate.
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KEYWORD
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Grewia asiatica, Dementia, Nootropics, Acetylcholinesterase, Scopolamine, Oxidative stress
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