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KMID : 1200820200200030451
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 3 p.451 ~ p.459
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Investigation of antinociceptive, anti-inflammatory and thrombolytic activity of Caesalpinia digyna (Rottl.) leaves by experimental and computational approaches
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Emon Nazim Uddin
Jahan Israt
Sayeed Mohammed Aktar
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Abstract
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The study aimed to report in vitro thrombolytic and in vivo anti-nociceptive activity of methanolic extract of Caesalpinia digyna (MECD) followed by in silico PASS prediction, ADME analysis with toxicity and molecular docking study of antinociception (Cox-1, Cox-2) and thrombolytic (Tissue plasminogen activator). The clot lysis of human blood for thrombolytic study, acetic acid induced writing and formalin-induced licking in mice at several doses (50, 100, 200 and 400 mg/kg, b.w.; p.o.) of MECD for anti-inflammatory and antinoceptive activities were performed. In thrombolytic study, a significant 32.78% (P?
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KEYWORD
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Antinociceptive, Caesalpinia digyna, Thrombolytic, Caesalpinine A, Caesalpinine C, Molecular docking
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