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KMID : 1200820200200040545
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 4 p.545 ~ p.554
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Hepatoprotective effects of Meconopsis aculeata extract against CCl4 induced oxidative damage in rats
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Hassan Sumaya
Bhat Muzaffar Ahmad
Sajjad Nasreena
Ali Rohaya
Ganie Showkat Ahmad
Hamid Rabia
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Abstract
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The objective of the present study was to investigate the hepatoprotective effects of methanol extract of Meconopsis aculeata, an important medicinal plant of Kashmir Himalayas, against CCl4 induced oxidative damage in rats. Acute hepatotoxicity was induced in Wistar albino rats by single intraperitoneal injection of CCl4 at 1 ml/kg body weight dose. Methanol extract of M. aculeata was orally administered at the doses of 100, 200 and 300 mg/kg body weight/day for 14 days. The results revealed that administration of CCl4 caused a significant increase in serum AST, ALT and LDH levels as compared to the control group (p?
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KEYWORD
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Antioxidant, CCl4, Hepatoprotective, Meconopsis aculeata
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