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KMID : 1200820200200040591
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 4 p.591 ~ p.598
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Study of the antifungal potential of carvacrol on growth inhibition of Candida krusei in a systemic candidiasis
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Feridoniy Moslem
Alizadeh Fahimeh
Kokhdan Esmaeel Panahi
Khodavandi Alireza
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Abstract
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Candidiasis caused by non-albicans Candida species present a serious global health threat. Although the available antifungal drugs are recommended, resistance phenomenon of these agents is beginning to emerge, demonstrating the urgently need for new and effective antifungal agents. Here, we have aimed to describe the antifungal activity of carvacrol against Candida krusei both in vitro and in a systemic candidiasis mouse model. In vitro susceptibility of C. krusei isolates to carvacrol were assessed using the Clinical and Laboratory Standards Institute broth microdilution reference method. In vivo, carvacrol was evaluated in murine models of systemic candidiasis by determination of fungal loads of kidneys, survival time and histopathologic analyses. Carvacrol exhibit minimum inhibitory concentration in the 6.00?±?2.80 μg/mL to 8.00?±?0.00 μg/mL range. In vivo, carvacrol decreased fungal load of kidneys (p?
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KEYWORD
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Animal models, Candida, Candidiasis, Fluconazole, In vitro
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