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KMID : 1200820200200040681
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 4 p.681 ~ p.684
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Effect of Astragalus membranaceus extract on IgA nephropathy: a case of renal function improvement during one-and-a-half-year follow-up
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Lwin Khin Maung
Linn Ye Htut
Dee Yamin Kyaw Swar
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Abstract
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Immunoglobulin A nephropathy is one of the most common type of primary glomerulonephritis globally. Its pathogenesis remains unclear. It is a slowly progressive disease that may eventually lead to end-stage renal disease. Although the angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, and immunosuppressive drugs are regarded as the standard treatments, the optimal approach to the treatment of IgA nephropathy is still uncertain. Astragalus membranaceus has been widely used in traditional Chinese medicine for cardiovascular disorder, kidney disease, hepatitis, and some skin diseases. It had been widely used in treating various renal diseases including IgA nephropathy. In this case report, we present a 34-year-old Myanmar female of Karen ethnic with IgA nephropathy. She was treated with Astragalus membranaceus together with losartan and other integrative medicines. Her renal function and proteinuria improved during the one-a-half-year follow-up. This case report highlights the improvement effect of Astragalus membranaceus in integrative way for the treatment of IgA nephropathy.
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KEYWORD
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IgA nephropathy, Astragalus membranaceus, Astragaloside IV
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