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KMID : 1200820210210020297
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Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 2 p.297 ~ p.304
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Neuromodulatory activity of trevo on cyanide-induced neurotoxicity viz neurochemical, antioxidants, cytochrome C oxidase and p53
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Ilesanmi Omotayo Babatunde
Ikpesu Thomas
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Abstract
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Potassium cyanide (KCN) is a salt that release cyanide upon degradation in living system. Cyanide is a chemical that induced its toxicity and lethal effect through the inhibition of cytochrome C oxidase activity. Trevo, a phytochemical rich product is majorly used for its antiaging and disease prevention among individuals. We evaluated the potential of trevo to reverse the biochemical toxicity of cyanide in the brain of male wistar rats. The biochemical changes assessed are- cytochrome C oxidase (CCO), neurochemicals (acetylcholine esterase (ACHE), dopamine and serotonin), and p53, antioxidants (catalase (CAT) and superoxide dismutase (SOD) and malonedialdehyde (MDA). KCN significantly inhibited the activity of CCO, CAT and SOD, increased the level of p53, AChE and MDA as well as decreased the level of dopamine and serotonin. Early administration of trevo caused a reversal of all these biochemical at varying degree. Histological results showed that KCN had no observable effect on the morphology of the brain. Further work can be done on the effect of trevo on long-term exposure to KCN.
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KEYWORD
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Potassium cyanide, Trevo, Cytochrome C oxidase, Neurochemicals, p53, Antioxidant
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